گزارش ۱۰ مورد درمان کراتوآکانتوما با تزریق متوترکسات داخل ضایعه

ABSTRACT: Keratoacanthoma is a benign self-limited skin tumor. Because it often involutes spontaneously,some believe that K.A should merely be observed .However treatment in some unusual cases may hasten resolution improve cosmetic result and also if a squamous cell carcinoma is misdiagnosed as a K.A,it continues to expand. we report an open clinical uncontrolled study of 10 cases treated successfully with intralesional MTX.All lesions responded with complete resolution after a mean of 1.5 week without any side effects and mild scarring . In conclusion, intralesional MTX is a simple and very effective modality for treatment of selected cases and may offer greater efficacy ,rapid response ,mild pain and lower cost compared with intralesional 5FU.